Genetic load has potential in large populations but is realized in small inbred populations
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چکیده
منابع مشابه
Genetic rescue of small inbred populations: meta-analysis reveals large and consistent benefits of gene flow.
Many species have fragmented distribution with small isolated populations suffering inbreeding depression and/or reduced ability to evolve. Without gene flow from another population within the species (genetic rescue), these populations are likely to be extirpated. However, there have been only ~ 20 published cases of such outcrossing for conservation purposes, probably a very low proportion of...
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The mouse is the most extensively used mammalian model for biomedical and aging research, and an extensive catalogue of laboratory resources is available to support research using mice: classical inbred lines, genetically modifi ed mice (knockouts, transgenics, and humanized mice), selectively bred lines, consomics, congenics, recombinant inbred panels, outbred and heterogeneous stocks, and an ...
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HE mutation load has been defined as the proportion by which the population fitness, or any other attribute of interest, is altered by recurrent mutation (MORTON, CROW, and MULLER 1956; CROW 1958). HALDANE (1937) and MULLER (1950) had earlier shown that this load is largely independent of the harmfulness of the mutant. As long as the selective disadvantage of the mutant is of a larger order of ...
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This paper looks at the use of small populations in Genetic Programming (GP), where the trend in the literature appears to be towards using as large a population as possible, which requires more memory resources and CPU-usage is less e cient. Dynamic Subset Selection (DSS) and Limited Error Fitness (LEF) are two different, adaptive variations of the standard supervised learning method used in G...
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ژورنال
عنوان ژورنال: Evolutionary Applications
سال: 2021
ISSN: 1752-4571,1752-4571
DOI: 10.1111/eva.13216